pena35

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penicillin-binding protein 2

NCBI Pathogen Isolates

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UniProt

Protein entries specific to pena35

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Validation StatusCandidate

Overview

Mechanism: chromosomally mediated intermediate resistance to ceftriaxone and cefixime
Validation Method: transformation and MIC measurement
Drug Classes: ceftriaxone, cefixime
Organisms: Neisseria gonorrhoeae
Papers: 1
Databases: Reslit

Papers1

Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae.

PMID 19528266 · 2009

The study identifies the mosaic penA35 allele as a significant contributor to intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae, alongside mtrR and penB mutations.

Gene Information

Gene Name: pena35
Allele: penA35
Encodes: penicillin-binding protein 2
Source Database: Reslit
Mechanism: chromosomally mediated intermediate resistance to ceftriaxone and cefixime
Confers Resistance To: ceftriaxonecefixime
Organisms Tested In: • Neisseria gonorrhoeae
Validation Method: transformation and MIC measurement

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pena35

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pena35

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