pena41

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Penicillin-binding protein 2

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UniProt

Protein entries specific to pena41

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Validation StatusCandidate

Overview

Validation Method: transformation of resistance determinants into susceptible strain FA19 and determination of MICs
Drug Classes: ceftazidime, ceftriaxone
Organisms: Neisseria gonorrhoeae H041
Papers: 1
Databases: Reslit

Papers1

Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041.

PMID 38446051 · 2024

The study identifies penA41 as a key determinant of resistance to β-lactams in multidrug-resistant Neisseria gonorrhoeae H041, highlighting its role in reducing susceptibility to ceftazidime and ceftriaxone.

Gene Information

Gene Name: pena41
Allele: penA41
Encodes: Penicillin-binding protein 2
Source Database: Reslit
Confers Resistance To: ceftazidimeceftriaxone
Organisms Tested In: • Neisseria gonorrhoeae H041
Validation Method: transformation of resistance determinants into susceptible strain FA19 and determination of MICs

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pena41

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pena41

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