pena795

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PBP2-TPase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to pena795

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Validation StatusCandidate

Overview

Mechanism: mutation in penA gene leading to cefotaxime resistance
Validation Method: experimental validation via MIC testing and sequencing
Drug Classes: cefotaxime, penicillin, ceftriaxone, ciprofloxacin
Organisms: Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria commensals
Geographic Location: Shanghai, China
Papers: 1
Databases: Reslit

Papers1

Cefotaxime-Resistant Neisseria meningitidis Sequence Type 4821 Causing Fulminant Meningitis.

PMID 40023817 · 2025

The study identifies the penA795 allele, which encodes a PBP2-TPase variant responsible for cefotaxime resistance in Neisseria meningitidis. This allele was found in commensal Neisseria isolates and was horizontally transferred to a quinolone-resistant N. meningitidis ST4821 strain, causing fulminant meningitis.

Gene Information

Gene Name: pena795
Allele: penA795
Encodes: PBP2-TPase
Source Database: Reslit
Mechanism: mutation in penA gene leading to cefotaxime resistance
Confers Resistance To: cefotaximepenicillinceftriaxoneciprofloxacin
Organisms Tested In: • Neisseria meningitidis
• Neisseria gonorrhoeae
• Neisseria commensals
Geographic Location: Shanghai, China
Validation Method: experimental validation via MIC testing and sequencing
Sequence Accession: https://pubmlst.org/neisseria

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pena795

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pena795

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