pena_253

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penicillin-binding protein 2

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to pena_253

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: reduced affinity for penicillin
Validation Method: transformation of penA_253 into penicillin-sensitive isolates and subsequent Etest
Drug Classes: penicillin
Organisms: Neisseria meningitidis
Geographic Location: Australia
Papers: 1
Databases: Reslit

Papers1

Clonal Expansion of New Penicillin-Resistant Clade of Neisseria meningitidis Serogroup W Clonal Complex 11, Australia.

PMID 28609259 · 2017

The study identifies the penA_253 allele as a major contributor to penicillin resistance in a new clade of Neisseria meningitidis serogroup W clonal complex 11 in Australia.

Gene Information

Gene Name: pena_253
Allele: penA_253
Encodes: penicillin-binding protein 2
Source Database: Reslit
Mechanism: reduced affinity for penicillin
Confers Resistance To: penicillin
Organisms Tested In: • Neisseria meningitidis
Geographic Location: Australia
Validation Method: transformation of penA_253 into penicillin-sensitive isolates and subsequent Etest

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pena_253

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pena_253

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