Browse AMR Genes

Explore antimicrobial resistance genes from the literature

pepA

protease

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to pepA

Browse AMR rules for pepA

Overview

Drug Classes: cefuroxime, aztreonam
Organisms: Pseudomonas aeruginosa
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T157P	-	-	Pseudomonas aeruginosa	cefuroxime	Reslit	Candidate
Y264C	-	-	Pseudomonas aeruginosa	aztreonam	Reslit	Candidate

Papers2

1

High potency of sequential therapy with only β-lactam antibiotics.

PMID 34318749 · 2021

Mutation Information

Protein Change: T157P
Organisms: Pseudomonas aeruginosa
Confers Resistance To: cefuroxime
Validation Method: Whole-genome sequencing and resistance profiling
Source Database: Reslit

2

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa.

PMID 29089424 · 2017

Mutation Information

Protein Change: Y264C
Organisms: Pseudomonas aeruginosa
Confers Resistance To: aztreonam
Validation Method: whole-genome sequencing
Source Database: Reslit