pflB

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pyruvate formate lyase B

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to pflB

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Validation StatusCandidate

Overview

Validation Method: RT-qPCR and proteomic analysis
Drug Classes: fosfomycin
Organisms: Staphylococcus aureus
Papers: 1
Databases: Reslit

Papers1

Coordinated regulation of transcription by CcpA and the Staphylococcus aureus two-component system HptRS.

PMID 30540769 · 2018

Inactivation of ccpA and hptRS altered sensitivity to fosfomycin and ampicillin in the absence of exogenous glucose-6-phosphate, indicating that both CcpA and HptRS modulate antibiotic susceptibility.

Gene Information

Gene Name: pflB
Allele: pflB
Encodes: pyruvate formate lyase B
Source Database: Reslit
Confers Resistance To: fosfomycin
Organisms Tested In: • Staphylococcus aureus
Validation Method: RT-qPCR and proteomic analysis
Sequence Accession: PXD008708

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pflB

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pflB

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