pgaB

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protein

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Validation StatusCandidate

Overview

Mechanism: overexpression facilitates PNAG-deacetylation, contributing to OMV production and PMB resistance
Validation Method: transcriptomic and proteomic analyses
Drug Classes: polymyxin b
Organisms: Acinetobacter baumannii
Papers: 1
Databases: Reslit

Papers1

A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii.

PMID 34180396 · 2021

The study identifies pmrC as a gene that confers resistance to polymyxin B by modifying lipid A with phosphoethanolamine, reducing the negative charge of the cell membrane and decreasing PMB binding.

Gene Information

Gene Name: pgaB
Allele: pgaB
Encodes: protein
Source Database: Reslit
Mechanism: overexpression facilitates PNAG-deacetylation, contributing to OMV production and PMB resistance
Confers Resistance To: polymyxin b
Organisms Tested In: • Acinetobacter baumannii
Validation Method: transcriptomic and proteomic analyses
Sequence Accession: CP000521|CP015122.1|PRJNA530195|PRJNA530197|PRJNA530202

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pgaB

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pgaB

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