pgk

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Phosphoglycerate kinase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

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Validation StatusCandidate

Overview

Mechanism: Inactivation of pgk leads to reduced enzymatic activity, contributing to fosfomycin resistance.
Validation Method: Complementation experiments showed that introducing the wild-type pgk gene restored susceptibility to fosfomycin.
Drug Classes: fosfomycin
Organisms: Stenotrophomonas maltophilia
Papers: 1
Databases: Reslit

Papers1

The Inactivation of Enzymes Belonging to the Central Carbon Metabolism Is a Novel Mechanism of Developing Antibiotic Resistance.

PMID 32487742 · 2020

The study identifies mutations in genes encoding enzymes of the Embden-Meyerhof-Parnas (EMP) metabolic pathway as a novel mechanism of fosfomycin resistance in Stenotrophomonas maltophilia.

Gene Information

Gene Name: pgk
Allele: pgk
Encodes: Phosphoglycerate kinase
Source Database: Reslit
Mechanism: Inactivation of pgk leads to reduced enzymatic activity, contributing to fosfomycin resistance.
Confers Resistance To: fosfomycin
Organisms Tested In: • Stenotrophomonas maltophilia
Validation Method: Complementation experiments showed that introducing the wild-type pgk gene restored susceptibility to fosfomycin.
Sequence Accession: NCBI:CP041005|SRX8197527|SRX8197528|SRX8197529|SRX8197530|GSE141276

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pgk

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pgk

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