phnE

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integral membrane component of the importer

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Validation StatusCandidate

Overview

Mechanism: phosphonate uptake and degradation
Validation Method: transposon insertion and MIC testing
Drug Classes: fosfomycin
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

A genome-wide analysis of Escherichia coli responses to fosfomycin using TraDIS-Xpress reveals novel roles for phosphonate degradation and phosphate transport systems.

PMID 32756955 · 2020

The study identifies novel roles for phosphonate degradation and phosphate transport systems in fosfomycin susceptibility in Escherichia coli, revealing new mechanisms of resistance through transposon mutagenesis and validation experiments.

Gene Information

Gene Name: phnE
Allele: phnE
Encodes: integral membrane component of the importer
Source Database: Reslit
Mechanism: phosphonate uptake and degradation
Confers Resistance To: fosfomycin
Organisms Tested In: • Escherichia coli
Validation Method: transposon insertion and MIC testing
Sequence Accession: PRJEB29311

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phnE

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phnE

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