phnP

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putative metal-dependent hydrolase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to phnP

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: disruption
Validation Method: mutant strain construction and phenotypic analysis
Drug Classes: ceftriaxone
Organisms: Enterococcus faecalis
Papers: 1
Databases: Reslit

Papers1

Functional Genomics of Antibiotic Susceptibility in Enterococcus faecalis From Infective Endocarditis.

PMID 40444324 · 2025

The study identifies pbp4-82delT and phnP disruptions as contributing to decreased susceptibility to ceftriaxone and ampicillin in Enterococcus faecalis isolates from infective endocarditis.

Gene Information

Gene Name: phnP
Allele: phnP
Encodes: putative metal-dependent hydrolase
Source Database: Reslit
Mechanism: disruption
Confers Resistance To: ceftriaxone
Organisms Tested In: • Enterococcus faecalis
Validation Method: mutant strain construction and phenotypic analysis
Sequence Accession: PRJNA729754

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phnP

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phnP

Gene Information