Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
outer membrane porin
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| PhoE | Reslit | 1 | beta lactams | Escherichia coli +1 | Pakistan | 2020 | SRR11108934|SRR11108933|6V78|PRJNA607402 | - |
| phoE | Reslit | 2 | cefmetazole, beta lactams | Escherichia coli +1 | Japan | 2022, 2023 | CP023569|CP027111 | - |
Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in Klebsiella pneumoniae.
Loss of OmpK35 and OmpK36 porins significantly increases resistance to β-lactam antibiotics in Klebsiella pneumoniae. The study identifies OmpK38 as a new member of the general bacterial porin family and demonstrates that porin remodeling plays a critical role in antimicrobial resistance.
Cefmetazole Resistance Mechanism for Escherichia Coli Including ESBL-Producing Strains.
The study identified that decreased expression of porin genes ompF, ompC, and phoE contributes to cefmetazole resistance in E. coli, particularly in ESBL-producing strains. The addition of relebactam suppressed resistance acquisition.
The evolution of antibiotic resistance in an incurable and ultimately fatal infection: A retrospective case study.
The study identifies multiple mutations in genes such as ampD, deoR, wecA, rcsC, ompC, ompD, and phoE that contribute to antibiotic resistance in Enterobacter hormaechei. These mutations include transposon insertions, deletions, and frameshift variants, leading to resistance against β-lactams, carbapenems, and other antibiotics.
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