Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Type IV pilus secretin
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| E666K | - | single resistance variant | Neisseria gonorrhoeae | cefixime|penicillinpenicillin|tetracycline|ciprofloxacinbeta lactams | ReslitResFinder DatabaseCard Database | Candidate |
| S333N | - | - | Neisseria gonorrhoeae | ceftriaxone | Reslit | Candidate |
| - | - | - | Neisseria subflava | azithromycin | Reslit | Candidate |
| G590D | - | - | Neisseria gonorrhoeae | cefixime | Reslit | Candidate |
| 1566-1567ins | - | - | Neisseria gonorrhoeae | cefixime | Reslit | Candidate |
| G666L | - | - | Neisseria gonorrhoeae | penicillin|tetracycline | Reslit | Candidate |
| N640S | - | - | penicillin|cephalosporins|tetracycline | Reslit | Candidate | |
| D526N | - | - | penicillin|cephalosporins|tetracycline | Reslit | Candidate |
The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability.
The penC mutation in Neisseria gonorrhoeae, which confers resistance to penicillin and tetracycline, is caused by a point mutation in the pilQ gene (Glu-666 to Lys) that disrupts the formation of the SDS-resistant high-molecular-mass PilQ secretin complex.
Diffusion of antibiotics through the PilQ secretin in Neisseria gonorrhoeae occurs through the immature, sodium dodecyl sulfate-labile form.
The study identifies the pilQ2 mutation (E666K) in Neisseria gonorrhoeae, which increases resistance to penicillin by altering the PilQ secretin's ability to form SDS-resistant multimers, thereby affecting antibiotic permeation.
WGS to predict antibiotic MICs for Neisseria gonorrhoeae.
The study identifies various AMR genes and mutations in Neisseria gonorrhoeae that contribute to resistance against multiple antibiotics, including cefixime, penicillin, azithromycin, ciprofloxacin, and tetracycline. These findings are supported by WGS and multivariate linear regression models.
Antimicrobial Resistance Profiling and Phylogenetic Analysis of Neisseria gonorrhoeae Clinical Isolates From Kenya in a Resource-Limited Setting.
The study identified multiple AMR genes and mutations in Neisseria gonorrhoeae isolates from Kenya, including mutations in gyrA, parC, penA, ponA1, rpsJ, folP, mtrR, rpoB, pilQ, porB1b, and rplD, which confer resistance to fluoroquinolones, penicillins, cephalosporins, tetracyclines, sulfonamides, rifampicin, and macrolides.
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