piucd

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iron transport system

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to piucd

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Validation StatusCandidate

Overview

Mechanism: genomic deletion
Validation Method: MIC testing of piuA and piuC knockout mutants
Drug Classes: cefiderocol
Organisms: Pseudomonas aeruginosa
Geographic Location: Spain
Papers: 1
Databases: Reslit

Papers1

Emergence of cefiderocol resistance during ceftazidime/avibactam treatment caused by a large genomic deletion, including ampD and piuCD genes, in Pseudomonas aeruginosa.

PMID 38063398 · 2024

The study reports the emergence of cefiderocol resistance in Pseudomonas aeruginosa due to a large genomic deletion encompassing ampD and piuCD genes, which was likely selected by ceftazidime/avibactam treatment.

Gene Information

Gene Name: piucd
Allele: piuCD
Encodes: iron transport system
Source Database: Reslit
Mechanism: genomic deletion
Confers Resistance To: cefiderocol
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Spain
Validation Method: MIC testing of piuA and piuC knockout mutants
Sequence Accession: PRJEB65984

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piucd

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piucd

Gene Information