Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
major outer membrane porin
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D142H | - | loss of calcium-binding site in channel | Campylobacter jejuni | ciprofloxacin | Reslit | Candidate |
| G56D | - | Efflux, group 2 major outer membrane porin protein PorA | Campylobacter jejuni | ertapenemertapenem|meropenemcarbapenems | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| ins139ND | - | Efflux | Campylobacter jejuni | ertapenem|meropenem | ResFinder Database | Candidate |
| ins139D | - | Efflux | Campylobacter jejuni | ertapenem|meropenem | ResFinder Database | Candidate |
| N138ND | - | group 2 major outer membrane porin protein PorA | Campylobacter jejuni | carbapenems | Reference Gene Catalog | Candidate |
| - | - | Campylobacter coli | - | Reslit | Candidate |
Resistance mechanisms in Campylobacter jejuni.
The paper reviews the resistance mechanisms in Campylobacter jejuni, focusing on fluoroquinolone, macrolide, beta-lactam, tetracycline, and aminoglycoside resistance. Key mechanisms include mutations in gyrA, efflux pumps like CmeABC, modifications of 23S rRNA, and the presence of resistance genes such as aphA-3, TetO, and blaOXA-61.
Recurrent Campylobacter jejuni Infections with In Vivo Selection of Resistance to Macrolides and Carbapenems: Molecular Characterization of Resistance Determinants.
The study identifies porA mutations and blaOXA-61 and cmeABC efflux pump modifications as key contributors to carbapenem resistance in Campylobacter jejuni, highlighting the role of structural changes in porin proteins and efflux systems in mediating resistance.
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