Browse AMR Genes

Explore antimicrobial resistance genes from the literature

potA

ATPase subunit of the spermidine-preferential uptake system PotABCD

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to potA

Browse AMR rules for potA

Overview

Mechanism: increased gentamicin MIC
Drug Classes: gentamicin
Organisms: Escherichia coli
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q208L	-	increased gentamicin MIC	Escherichia coli	gentamicin	Reslit	Candidate

Papers1

1

Parallel Evolution of High-Level Aminoglycoside Resistance in Escherichia coli Under Low and High Mutation Supply Rates.

PMID 29615988 · 2018

Mutation Information

Protein Change: Q208L
Organisms: Escherichia coli
Confers Resistance To: gentamicin
Effect on Function: increased gentamicin MIC
Validation Method: complementation with wild-type potA gene
Source Database: Reslit