ppm1

polyprenol phosphate mannose synthase

Overview

Mechanism: increased susceptibility to multiple antibiotics
Drug Classes: ampicillin|imipenem|meropenem|rifampicin|vancomycin
Organisms: Streptomyces coelicolor
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
E218V	A654T	increased susceptibility to multiple antibiotics	Streptomyces coelicolor	ampicillin\|imipenem\|meropenem\|rifampicin\|vancomycin	Reslit	Candidate

Papers1

Streptomyces coelicolor strains lacking polyprenol phosphate mannose synthase and protein O-mannosyl transferase are hyper-susceptible to multiple antibiotics.

PMID 29458553 · 2018

ppm1 mutants show increased susceptibility to multiple antibiotics

Mutation Information

ppm1: p.E218V / c.A654T

Protein Change: E218V
Nucleotide Change: A654T
Organisms: Streptomyces coelicolor
Confers Resistance To: ampicillin|imipenem|meropenem|rifampicin|vancomycin
Effect on Function: increased susceptibility to multiple antibiotics
Validation Method: disc diffusion assay
Source Database: Reslit

ppm1

Mutations

Mutation Information

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ppm1

Mutations

Mutation Information