Browse AMR Genes

Explore antimicrobial resistance genes from the literature

prkC

serine/threonine-protein kinase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to prkC

Browse AMR rules for prkC

Overview

Drug Classes: daptomycin
Organisms: Staphylococcus aureus
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G18V	-	-	Staphylococcus aureus	daptomycin	Reslit	Candidate

Papers1

1

Novel Daptomycin Tolerance and Resistance Mutations in Methicillin-Resistant Staphylococcus aureus from Adaptive Laboratory Evolution.

PMID 34585959 · 2021

Mutation in prkC leads to mild daptomycin tolerance in TOL5.

Mutation Information

Protein Change: G18V
Organisms: Staphylococcus aureus
Confers Resistance To: daptomycin
Validation Method: whole-genome sequencing and survival assays
Source Database: Reslit