proP

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proline/betaine transporter

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to proP

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Validation StatusCandidate

Overview

Validation Method: proteomics and gene mutation analysis
Drug Classes: daptomycin
Organisms: Staphylococcus aureus
Papers: 1
Databases: Reslit

Papers1

Proteome profiling of evolved methicillin-resistant Staphylococcus aureus strains with distinct daptomycin tolerance and resistance phenotypes.

PMID 35992709 · 2022

The study identifies mprF, proP, ecsA1, and fabG as genes contributing to daptomycin resistance and tolerance in MRSA strains, with mutations in mprF playing a significant role in resistance mechanisms.

Gene Information

Gene Name: proP
Allele: proP
Encodes: proline/betaine transporter
Source Database: Reslit
Confers Resistance To: daptomycin
Organisms Tested In: • Staphylococcus aureus
Validation Method: proteomics and gene mutation analysis

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proP

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proP

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