pta

View on PubMed

phosphate acetyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to pta

AMR Rules

Browse AMR rules for pta

Validation StatusCandidate

Overview

Mechanism: mutation leads to reduced DAP tolerance
Validation Method: whole-genome sequencing and proteomics
Drug Classes: daptomycin
Organisms: Staphylococcus aureus
Papers: 1
Databases: Reslit

Papers1

Comparative proteomic investigation of multiple methicillin-resistant Staphylococcus aureus strains generated through adaptive laboratory evolution.

PMID 34458699 · 2021

The study identifies mutations in mprF, pgsA, and pta genes that contribute to daptomycin resistance and tolerance in methicillin-resistant Staphylococcus aureus strains generated through adaptive laboratory evolution.

Gene Information

Gene Name: pta
Allele: pta
Encodes: phosphate acetyltransferase
Source Database: Reslit
Mechanism: mutation leads to reduced DAP tolerance
Confers Resistance To: daptomycin
Organisms Tested In: • Staphylococcus aureus
Validation Method: whole-genome sequencing and proteomics
Sequence Accession: PRJNA660918|PXD021667

Comments (0)

No comments yet. Be the first to comment!

pta

Gene Information

Browse AMR Genes

pta

Gene Information