ptr1

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pteridine reductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ptr1

AMR Rules

Browse AMR rules for ptr1

Validation StatusCandidate

Overview

Mechanism: R20fs mutation
Validation Method: genomic analysis
Drug Classes: sulfamethoxazole, trimethoprim sulfamethoxazole
Organisms: Burkholderia pseudomallei
Geographic Location: Australia, Australia|Malaysia|Southeast Asia
Papers: 3
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
20fs	20ins	-	Burkholderia pseudomallei	trimethoprim sulfamethoxazole	Reslit	Candidate

Papers3

Transcriptomic analysis of longitudinal Burkholderia pseudomallei infecting the cystic fibrosis lung.

PMID 29989529 · 2018

The study identifies upregulation of the RND efflux pumps bpeEF-oprC, amrAB-oprA, and penA duplication as mechanisms of resistance to ceftazidime, trimethoprim/sulfamethoxazole, and doxycycline/meropenem in Burkholderia pseudomallei isolates from cystic fibrosis patients.

Gene Information

Gene Name: ptr1
Allele: ptr1
Encodes: pteridine reductase
Source Database: Reslit
Mechanism: R20fs mutation
Confers Resistance To: sulfamethoxazole
Organisms Tested In: • Burkholderia pseudomallei
Geographic Location: Australia
Validation Method: genomic analysis
Sequence Accession: PRJNA398168|SRR6031143|SRR6031144|SRR6031145|SRR6031146|SRR6031147|SRR6031148|SRR6031149|SRR6031150|SRR6031151|SRR6031152|NC_006350.1|NC_006351.1|JYBG00000000|JYBH00000000|JYBI00000000|JYBJ00000000|JYBK00000000

Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei.

PMID 33285499 · 2021

The study presents ARDaP, a new tool for comprehensive antimicrobial resistance (AMR) detection in Burkholderia pseudomallei. ARDaP accurately identifies various AMR determinants, including mutations in genes such as penA, bpeT, ptr1, metF, dut, bpsl3085, and amrR, which confer resistance to antibiotics like ceftazidime, meropenem, co-trimoxazole, and doxycycline.