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ramA

General Bacterial Porin with reduced permeability to beta-lactams;resistance-nodulation-cell division (RND) antibiotic efflux pump

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to ramA

Browse AMR rules for ramA

Validation StatusEstablished

Overview

Mechanism: antibiotic efflux;reduced permeability to antibiotic
Drug Classes: colistin, tigecycline, piperacillin tazobactam|ceftazidime|levofloxacin|tigecycline|doxycycline|minocycline, fluoroquinolones
Organisms: Enterobacter cloacae, Enterobacter hormaechei, Klebsiella pneumoniae, Klebsiella quasipneumoniae, Salmonella enterica
Papers: 5
Databases: Card Database
Mutations: 5

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
E83A	-	increased expression	Enterobacter cloacae, Enterobacter hormaechei	colistin	Reslit	Candidate
W37K	-	-	Enterobacter cloacae	tigecycline	Reslit	Candidate
H31D	-	-	Klebsiella pneumoniae	piperacillin tazobactam\|ceftazidime\|levofloxacin\|tigecycline\|doxycycline\|minocycline	Reslit	Candidate
H38Y	-	-	Klebsiella pneumoniae, Klebsiella quasipneumoniae	colistin	Reslit	Candidate
-	G499A	-	Salmonella enterica	fluoroquinolones	Reslit	Candidate

Papers5

1

Gene Information

Gene Name: ramA
Allele: ramA
Encodes: General Bacterial Porin with reduced permeability to beta-lactams;resistance-nodulation-cell division (RND) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux;reduced permeability to antibiotic
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: JQ727668.1
Protein Accession: AFK13828.1
Notes: ARO:3000823

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