Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
DNA repair protein
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| recA | Reslit | 5 | metronidazole, fluoroquinolones +3 | Bacteroides fragilis +6 | - | 2010, 2015, 2022, 2023, 2025 | AL513382.1 | - |
| RecA | Reslit | 1 | ciprofloxacin | Escherichia coli | - | 2025 | - | - |
Bacteroides fragilis RecA protein overexpression causes resistance to metronidazole.
Overexpression of the RecA protein in Bacteroides fragilis increases resistance to metronidazole, representing a novel drug resistance mechanism in this bacterium.
Overexpression of Salmonella enterica serovar Typhi recA gene confers fluoroquinolone resistance in Escherichia coli DH5α.
Overexpression of the recA gene from Salmonella enterica serovar Typhi confers selective fluoroquinolone resistance in Escherichia coli DH5α.
Pseudomonas aeruginosa heteroresistance to levofloxacin caused by upregulated expression of essential genes for DNA replication and repair.
The study identifies that upregulated expression of genes involved in DNA replication and repair, such as recA, uvrD, xseB, ssb, mutM, and crc, contributes to levofloxacin heteroresistance in Pseudomonas aeruginosa strains PAS71 and PAS81. Additionally, the expression of genes related to bacterial secretion systems, such as gspD, vgrG1, hcpC, clpV1, and ppkA, is increased in PAS81 under LVX stress.
Resistance mechanisms of tigecycline in Acinetobacter baumannii.
The study identifies several efflux pumps, outer membrane permeability alterations, and antibiotic target modifications as key mechanisms of tigecycline resistance in Acinetobacter baumannii.
Environmental resistome-guided development of resistance-tolerant antibiotics.
The study identifies eight distinct resistance gene classes from the environmental resistome of albicidin, including AraC family proteins, HlyD family transporters, RecA recombinases, hydrolases, a MerR family protein, a pentapeptide repeat protein, a glutathione S-transferase-like protein, and a monooxygenase. These genes confer varying levels of resistance to albicidin through mechanisms such as efflux, degradation, sequestration, and modification.
Evaluating the predictive power of combined gene expression dynamics from single cells on antibiotic survival.
The study identifies that increased expression of the gadX gene correlates with ciprofloxacin survival in E. coli, while growth rate has a negative impact on survival. The recA gene's expression also influences survival, but to a lesser extent.
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