recG

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RecG helicase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to recG

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: non-synonymous mutation leading to fluoroquinolone resistance
Validation Method: plasmid complementation and MIC testing
Drug Classes: ciprofloxacin
Organisms: Escherichia coli, E. coli
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A109T	-	-	E. coli	ciprofloxacin	Reslit	Candidate

Papers1

Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates.

PMID 23824211 · 2013

The study identifies novel SNPs in gyrA, mutM, ligB, and recG genes associated with fluoroquinolone resistance in E. coli clinical isolates, demonstrating their role in resistance mechanisms through experimental validation.

Gene Information

Gene Name: recG
Allele: recG
Encodes: RecG helicase
Source Database: Reslit
Mechanism: non-synonymous mutation leading to fluoroquinolone resistance
Confers Resistance To: ciprofloxacin
Organisms Tested In: • Escherichia coli
Validation Method: plasmid complementation and MIC testing
Sequence Accession: CP000948.1|CP000819.1|CP000970.1|NC_010488.1

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recG

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recG

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