Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
synthetase of the alarmone (p)ppGpp
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| A1067U | - | highly resistant | Escherichia coli, Bacillus subtilis | thiostrepton | Reslit | Candidate |
| A154E | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| R132C | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| S217L | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| L152F | - | Enterococcus faecium | linezolid|daptomycin | Reslit | Candidate |
Whole-genome sequencing reveals a link between β-lactam resistance and synthetases of the alarmone (p)ppGpp in Staphylococcus aureus.
Mutations in the relA and relQ genes, which encode (p)ppGpp synthetases, contribute to β-lactam resistance in Staphylococcus aureus by altering (p)ppGpp levels.
Genetic Determinants of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus.
The study identified six genes (fruB, gmk, hpt, purB, prsA, and relA) that are mutated in highly oxacillin-resistant strains of MRSA, highlighting the role of guanine metabolism in determining antibiotic resistance.
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