relQ

View on PubMed

synthetase of the alarmone (p)ppGpp

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to relQ

AMR Rules

Browse AMR rules for relQ

Validation StatusCandidate

Overview

Mechanism: mutations in relQ lead to decreased (p)ppGpp levels, reducing β-lactam resistance
Validation Method: whole-genome sequencing and measurement of (p)ppGpp accumulation
Drug Classes: beta lactams
Organisms: Staphylococcus aureus
Papers: 1
Databases: Reslit

Papers1

Whole-genome sequencing reveals a link between β-lactam resistance and synthetases of the alarmone (p)ppGpp in Staphylococcus aureus.

PMID 23659600 · 2013

Mutations in the relA and relQ genes, which encode (p)ppGpp synthetases, contribute to β-lactam resistance in Staphylococcus aureus by altering (p)ppGpp levels.

Gene Information

Gene Name: relQ
Allele: relQ
Encodes: synthetase of the alarmone (p)ppGpp
Source Database: Reslit
Mechanism: mutations in relQ lead to decreased (p)ppGpp levels, reducing β-lactam resistance
Confers Resistance To: beta lactams
Organisms Tested In: • Staphylococcus aureus
Validation Method: whole-genome sequencing and measurement of (p)ppGpp accumulation

Comments (0)

No comments yet. Be the first to comment!

relQ

Gene Information

Browse AMR Genes

relQ

Gene Information