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rfaF

lipopolysaccharide (LPS) core heptose transferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to rfaF

Browse AMR rules for rfaF

Validation StatusCandidate

Overview

Validation Method: knockout and complementation experiments with MIC testing
Drug Classes: amoxicillin, tetracycline, clarithromycin, phenicols, amoxicillin|tetracycline|clarithromycin|phenicols
Organisms: Helicobacter pylori 11,637, H. pylori, H. pylori 11,637, H. pylori MDR, Helicobacter pylori
Papers: 1
Databases: Reslit
Mutations: 9

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
K331R	-	-	Helicobacter pylori	amoxicillin\|tetracycline\|clarithromycin\|phenicols	Reslit	Candidate
I59A	-	-	Helicobacter pylori	amoxicillin\|tetracycline\|clarithromycin\|phenicols	Reslit	Candidate
L345F	-	-	Helicobacter pylori	amoxicillin\|tetracycline\|clarithromycin\|phenicols	Reslit	Candidate
P192L	-	-	Helicobacter pylori	amoxicillin\|tetracycline\|clarithromycin\|phenicols	Reslit	Candidate
A341T	-	-	Helicobacter pylori	amoxicillin\|tetracycline\|clarithromycin\|phenicols	Reslit	Candidate
S250N	-	-	Helicobacter pylori	amoxicillin\|tetracycline\|clarithromycin\|phenicols	Reslit	Candidate
A276T	-	-	Helicobacter pylori	amoxicillin\|tetracycline\|clarithromycin\|phenicols	Reslit	Candidate
A342T	-	-	Helicobacter pylori	amoxicillin\|tetracycline\|clarithromycin\|phenicols	Reslit	Candidate
E198K	-	-	Helicobacter pylori	amoxicillin\|tetracycline\|clarithromycin\|phenicols	Reslit	Candidate

Papers1

1

A Newly Discovered Drug Resistance Gene rfaF In Helicobacter pylori.

PMID 31814739 · 2019

Gene Information

Gene Name: rfaF
Allele: rfaF
Encodes: lipopolysaccharide (LPS) core heptose transferase
Source Database: Reslit
Confers Resistance To: amoxicillintetracyclineclarithromycinphenicols
Organisms Tested In: • Helicobacter pylori 11,637
• H. pylori
• H. pylori 11,637
• H. pylori MDR
Validation Method: knockout and complementation experiments with MIC testing

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