Browse AMR Genes

Explore antimicrobial resistance genes from the literature

rfaH

transcriptional antiterminator

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to rfaH

Browse AMR rules for rfaH

Overview

Drug Classes: carbapenems
Organisms: Klebsiella pneumoniae
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q18*	C52T	-	Klebsiella pneumoniae	carbapenems	Reslit	Candidate

Papers1

1

Prevalence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae under divergent evolutionary patterns.

PMID 35844192 · 2022

rfaH mutation reduces capsular synthesis and increases carbapenem resistance

Mutation Information

rfaH: p.Q18* / c.C52T

Protein Change: Q18*
Nucleotide Change: C52T
Organisms: Klebsiella pneumoniae
Confers Resistance To: carbapenems
Validation Method: whole-genome resequencing and complementation
Source Database: Reslit