rgt1438

rifampin glycosyltransferase

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: disruption in the bacterial chromosome, resulting in a loss of antibiotic inactivation and a 4-fold decrease in MIC
Drug Classes: rifampicin
Organisms: Streptomyces sp. WAC 01438, Streptomyces speibonae, Rhodococcus erythropolis, Streptomyces albus J1074
Papers: 1
Databases: Card DatabaseReslit

Papers1

PMID N/A

Gene Information

Gene Name: rgt1438
Allele: rgt1438
Encodes: rifampin glycosyltransferase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Streptomyces sp. WAC 01438
Sequence Accession: JX028276.1
Protein Accession: AFO53532.1
Notes: ARO:3002883

Characterization of a Rifampin-Inactivating Glycosyltransferase from a Screen of Environmental Actinomycetes.

PMID 22802246 · 2012

The study identifies rgt1438 as a rifampin resistance determinant from WAC1438 that inactivates rifampin through glycosylation, demonstrating a new mechanism of rifampin resistance.

Gene Information

Gene Name: rgt1438
Allele: rgt1438
Encodes: glycosyltransferase
Source Database: Reslit
Mechanism: glycosylation
Confers Resistance To: rifampicin
Organisms Tested In: • Streptomyces speibonae
• Rhodococcus erythropolis
• Streptomyces albus J1074
Validation Method: disruption in the bacterial chromosome, resulting in a loss of antibiotic inactivation and a 4-fold decrease in MIC
Sequence Accession: JX028276

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rgt1438

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rgt1438

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