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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
lumazine synthase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R58H | - | - | Klebsiella pneumoniae, Enterobacter cloacae, Citrobacter freundii, Escherichia coli, Klebsiella michiganensis | nitrofurantoin | Reslit | Candidate |
| D203E | - | - | Klebsiella pneumoniae, Enterobacter cloacae, Citrobacter freundii, Escherichia coli, Klebsiella michiganensis | nitrofurantoin | Reslit | Candidate |
| V42I | - | - | Klebsiella pneumoniae, Enterobacter cloacae, Citrobacter freundii, Escherichia coli, Klebsiella michiganensis | nitrofurantoin | Reslit | Candidate |
| P55H | - | - | - | nitrofurantoin | Reslit | Candidate |
An in vitro deletion in ribE encoding lumazine synthase contributes to nitrofurantoin resistance in Escherichia coli.
The study identifies a 12-nucleotide deletion in the ribE gene, encoding lumazine synthase, as a novel determinant of nitrofurantoin resistance in Escherichia coli. Mutations in nfsA and nfsB were also found to contribute to resistance.
Characterization of Fosfomycin and Nitrofurantoin Resistance Mechanisms in Escherichia coli Isolated in Clinical Urine Samples.
The study identifies fosA3 as a novel plasmid-mediated fosfomycin resistance gene in E. coli isolates in Spain. Fosfomycin resistance is primarily due to defects in the UhpT transporter system, while nitrofurantoin resistance involves mutations in nfsA, nfsB, and ribE genes.
Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective Treatment.
This review discusses the molecular basis of challenges to effective treatment of UPEC-associated urinary tract infections, focusing on virulence factors and antibiotic resistance mechanisms.
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