rlmN

ribosomal RNA methyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to rlmN

Browse AMR rules for rlmN

Overview

Mechanism: inhibits the endogenous RlmN C2 methylation of A2503
Drug Classes: tiamulin, linezolid|quinupristin dalfopristin
Organisms: E. coli, Staphylococcus aureus
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q89R	-	inhibits the endogenous RlmN C2 methylation of A2503	E. coli	tiamulin	Reslit	Candidate
M1T	-	-	Staphylococcus aureus	linezolid\|quinupristin dalfopristin	Reslit	Candidate

Papers2

1

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.

PMID 27496281 · 2016

Mutations promoted from gene entry 'rlmn' (model emitted mutations_found inside genes).

Mutation Information

Protein Change: Q89R
Organisms: E. coli
Confers Resistance To: tiamulin
Effect on Function: inhibits the endogenous RlmN C2 methylation of A2503
Validation Method: antibiotic susceptibility test
Source Database: Reslit

2

In vivo evolution of antimicrobial resistance in a series of Staphylococcus aureus patient isolates: the entire picture or a cautionary tale?

PMID 24047554 · 2014

Mutation Information

Protein Change: M1T
Organisms: Staphylococcus aureus
Confers Resistance To: linezolid|quinupristin dalfopristin
Validation Method: whole-genome sequencing and variant analysis
Source Database: Reslit