rmte4

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16S rRNA methyltransferase

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UniProt

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Validation StatusCandidate

Overview

Validation Method: whole-genome sequencing and phenotypic resistance testing
Drug Classes: gentamicin, kanamycin, amikacin, neomycin, apramycin, streptomycin, plazomicin
Organisms: Klebsiella pneumoniae, Klebsiella quasipneumoniae
Geographic Location: Venezuela|Colombia
Papers: 1
Databases: Reslit

Papers1

Global scenario of the RmtE pan-aminoglycoside-resistance mechanism: emergence of the rmtE4 gene in South America associated with a hospital-related IncL plasmid.

PMID 36961505 · 2023

The study identifies a novel RmtE4 variant, which confers high-level resistance to all 4,6-DOS aminoglycosides, including plazomicin, and is associated with an IncL plasmid in Klebsiella isolates from Venezuela.

Gene Information

Gene Name: rmte4
Allele: rmtE4
Encodes: 16S rRNA methyltransferase
Source Database: Reslit
Confers Resistance To: gentamicinkanamycinamikacinneomycinapramycinstreptomycinplazomicin
Organisms Tested In: • Klebsiella pneumoniae
• Klebsiella quasipneumoniae
Geographic Location: Venezuela|Colombia
Validation Method: whole-genome sequencing and phenotypic resistance testing
Sequence Accession: PRJEB50384|CP075612|CP075613

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rmte4

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rmte4

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