rng

View on PubMed

ribonuclease G

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to rng

AMR Rules

Browse AMR rules for rng

Validation StatusCandidate

Overview

Mechanism: Regulates 16S rRNA processing, leading to accumulation of 16S+3∼7 precursors which reduces aminoglycoside binding
Validation Method: Deletion of rng in E. coli and Salmonella enterica serovar Typhimurium resulted in increased resistance to aminoglycosides
Drug Classes: kanamycin, neomycin, paromomycin, streptomycin, nalidixic acid
Organisms: Escherichia coli, Salmonella enterica serovar Typhimurium, Stenotrophomonas maltophilia
Papers: 2
Databases: Reslit

Papers2

Antibiotic stress-induced modulation of the endoribonucleolytic activity of RNase III and RNase G confers resistance to aminoglycoside antibiotics in Escherichia coli.

PMID 24489121 · 2014

Deletion of rnase_g leads to accumulation of 16S rRNA precursors with extra 3-8 nucleotides at the 5' end, resulting in resistance to aminoglycoside antibiotics.

Gene Information

Gene Name: rng
Allele: rng
Encodes: ribonuclease G
Source Database: Reslit
Mechanism: Regulates 16S rRNA processing, leading to accumulation of 16S+3∼7 precursors which reduces aminoglycoside binding
Confers Resistance To: kanamycinneomycinparomomycinstreptomycin
Organisms Tested In: • Escherichia coli
• Salmonella enterica serovar Typhimurium
Validation Method: Deletion of rng in E. coli and Salmonella enterica serovar Typhimurium resulted in increased resistance to aminoglycosides

The inactivation of RNase G reduces the Stenotrophomonas maltophilia susceptibility to quinolones by triggering the heat shock response.

PMID 26539164 · 2015

Inactivation of RNase G in Stenotrophomonas maltophilia leads to reduced susceptibility to quinolones by triggering the heat shock response.

Gene Information

Gene Name: rng
Allele: rng
Encodes: RNase G
Source Database: Reslit
Confers Resistance To: nalidixic acid
Organisms Tested In: • Stenotrophomonas maltophilia
Validation Method: transposon mutagenesis and complementation
Sequence Accession: SRR2128156

Comments (0)

No comments yet. Be the first to comment!

rng

View on PubMed

ribonuclease G

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to rng

AMR Rules

Browse AMR rules for rng

Validation StatusCandidate

Overview

Mechanism: Regulates 16S rRNA processing, leading to accumulation of 16S+3∼7 precursors which reduces aminoglycoside binding
Validation Method: Deletion of rng in E. coli and Salmonella enterica serovar Typhimurium resulted in increased resistance to aminoglycosides
Drug Classes: kanamycin, neomycin, paromomycin, streptomycin, nalidixic acid
Organisms: Escherichia coli, Salmonella enterica serovar Typhimurium, Stenotrophomonas maltophilia
Papers: 2
Databases: Reslit

Papers2

Antibiotic stress-induced modulation of the endoribonucleolytic activity of RNase III and RNase G confers resistance to aminoglycoside antibiotics in Escherichia coli.

PMID 24489121 · 2014

Deletion of rnase_g leads to accumulation of 16S rRNA precursors with extra 3-8 nucleotides at the 5' end, resulting in resistance to aminoglycoside antibiotics.

Gene Information

Gene Name: rng
Allele: rng
Encodes: ribonuclease G
Source Database: Reslit
Mechanism: Regulates 16S rRNA processing, leading to accumulation of 16S+3∼7 precursors which reduces aminoglycoside binding
Confers Resistance To: kanamycinneomycinparomomycinstreptomycin
Organisms Tested In: • Escherichia coli
• Salmonella enterica serovar Typhimurium
Validation Method: Deletion of rng in E. coli and Salmonella enterica serovar Typhimurium resulted in increased resistance to aminoglycosides

The inactivation of RNase G reduces the Stenotrophomonas maltophilia susceptibility to quinolones by triggering the heat shock response.

PMID 26539164 · 2015

Inactivation of RNase G in Stenotrophomonas maltophilia leads to reduced susceptibility to quinolones by triggering the heat shock response.

Gene Information

Gene Name: rng
Allele: rng
Encodes: RNase G
Source Database: Reslit
Confers Resistance To: nalidixic acid
Organisms Tested In: • Stenotrophomonas maltophilia
Validation Method: transposon mutagenesis and complementation
Sequence Accession: SRR2128156

Comments (0)

No comments yet. Be the first to comment!

rng

Gene Information

Gene Information

Browse AMR Genes

rng

Gene Information

Gene Information