The paper reviews the molecular mechanisms of resistance in Mycobacterium abscessus complex (MABC), highlighting the roles of erm(41), rrs, Bla_Mab, and MabTetX genes in conferring resistance to macrolides, aminoglycosides, beta-lactams, and tetracyclines respectively.

The paper reviews the genetic determinants of antibiotic resistance in Francisella, focusing on intrinsic resistance mechanisms and the roles of specific genes such as beta-lactamases, efflux pumps, and LPS modification genes.

The study identified various AMR genes and mutations in rapidly growing mycobacteria, including erm(41), rrl, rrs, and gyrA, which are associated with resistance to macrolides, aminoglycosides, and fluoroquinolones. The T28C mutation in erm(41) was linked to loss of macrolide resistance, while mutations in rrl and gyrA were associated with acquired resistance to macrolides and fluoroquinolones, respectively.

The study identifies several genes and mutations in Mycobacterium abscessus associated with resistance to various antibiotics and virulence, highlighting the genetic diversity and adaptability of the bacterium during chronic infection in cystic fibrosis patients.

The study identifies mutations in rrl, erm(41), and rrs genes associated with clarithromycin and amikacin resistance in Mycobacterium abscessus complex. These mutations were validated through melting curve analysis and phenotypic susceptibility testing.

The study identified the presence of the erm(41) gene associated with inducible macrolide resistance in M. abscessus subsp. abscessus and the MUT2 mutation in the rrl gene linked to constitutive resistance in M. abscessus subsp. massiliense.

The study demonstrated the effectiveness of MGIT-seq for identifying nontuberculous mycobacteria (NTM) and predicting drug resistance, particularly for macrolides and amikacin. Key findings include the identification of specific mutations in rrl, erm (41), and rrs genes associated with resistance.

The study identifies genomic rearrangements in the porin locus and mutations in the 23S rRNA gene (rrl) in Mycobacterium abscessus subspecies massiliense isolates from CF patients, leading to reduced porin expression and macrolide resistance.

The study identified mutations in erm (41), rrl, and rrs genes associated with clarithromycin and amikacin resistance in Mycobacterium abscessus complex isolates.

The study identifies numerous genetic mutations associated with resistance to various antibiotics in Mycobacterium tuberculosis, including rifampicin, isoniazid, ethambutol, fluoroquinolones, and linezolid. These findings enhance the understanding of AMR mechanisms and support the development of more accurate diagnostics and treatment strategies.

The study identified erm(41)T28 gene mutations associated with macrolide resistance in Mycobacterium abscessus subsp. abscessus. Additionally, rrl and rrs gene mutations were found to confer resistance to macrolides and aminoglycosides respectively.

The study identifies erm(41) and rrl gene mutations as markers for predicting macrolide susceptibility in Mycobacterium abscessus complex isolates, highlighting their role in acquired and inducible resistance mechanisms.

The study developed a novel PCR/MALDI-TOF MS platform for the identification of mycobacteria and detection of genetic markers of resistance, including erm(41), rrl, and rrs mutations associated with macrolide and aminoglycoside resistance.

The study identified N87K and D91N mutations in the gyrA gene associated with fluoroquinolone resistance and A2147G mutation in the rrl gene associated with clarithromycin resistance in Helicobacter pylori strains from Serbia.

The study identified several mutations in genes associated with resistance to amikacin, clarithromycin, linezolid, and moxifloxacin in Mycobacterium avium complex isolates.

The study identified resistance mechanisms in Mycobacterium abscessus isolates from cystic fibrosis patients, including inducible resistance to clarithromycin mediated by erm(41) mutations, acquired resistance to clarithromycin via rrl gene mutations, and amikacin resistance associated with rrs gene mutations.

The study found that the erm(41)28T mutation in Mycobacterium abscessus strongly predicts inducible clarithromycin resistance, while rrl gene mutations are also associated with clarithromycin resistance. However, other resistance mechanisms remain poorly understood.

The mlstverse system accurately identifies Mycobacterium abscessus subspecies and predicts drug resistance to clarithromycin and amikacin based on genetic analysis.

This study identified multiple mutations in the fgd1, fbiA, fbiC, rplC, and rrl genes associated with delamanid and linezolid resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Iran.

This study highlights the increasing global prevalence of macrolide resistance in Mycobacterium species, with significant variations observed across different countries, continents, and species.