rrs 1402c > t

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ribosomal RNA

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

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UniProt

Protein entries specific to rrs 1402c > t

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: mutation affecting ribosome structure
Validation Method: tNGS and ddPCR
Drug Classes: amikacin
Organisms: Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Targeted next-generation sequencing - a promising approach in the diagnosis of Mycobacterium tuberculosis and drug resistance.

PMID 39419957 · 2025

The study evaluated targeted next-generation sequencing (tNGS) for the diagnosis of Mycobacterium tuberculosis and detection of drug resistance. It identified a specific mutation (rrs 1402C > T) associated with amikacin resistance in MTB.

Gene Information

Gene Name: rrs 1402c > t
Allele: rrs 1402C > T
Encodes: ribosomal RNA
Source Database: Reslit
Mechanism: mutation affecting ribosome structure
Confers Resistance To: amikacin
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: tNGS and ddPCR

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rrs 1402c > t

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rrs 1402c > t

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