rrsH

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16S rRNA

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to rrsH

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Validation StatusCandidate

Overview

Mechanism: Altered ribosome sensitivity to tetracycline-class antibiotics
Validation Method: RNA-seq and smFRET imaging
Drug Classes: tetracycline
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype.

PMID 30282032 · 2018

The study identifies rrsH, a 16S rRNA variant, which alters ribosome sensitivity to tetracycline-class antibiotics, demonstrating that endogenous rRNA sequence variation can influence antibiotic resistance.

Gene Information

Gene Name: rrsH
Allele: rrsH
Encodes: 16S rRNA
Source Database: Reslit
Mechanism: Altered ribosome sensitivity to tetracycline-class antibiotics
Confers Resistance To: tetracycline
Organisms Tested In: • Escherichia coli
Validation Method: RNA-seq and smFRET imaging

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rrsH

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rrsH

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