Browse AMR Genes

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rsbW

anti-sigma factor RsbW

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to rsbW

Browse AMR rules for rsbW

Overview

Drug Classes: teicoplanin, oxacillin
Organisms: Staphylococcus aureus
Papers: 2
Mutations: 7

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
K44M	-	-	Staphylococcus aureus	teicoplanin	Reslit	Candidate
T52R	-	-	Staphylococcus aureus	teicoplanin	Reslit	Candidate
M1I	-	-	Staphylococcus aureus	teicoplanin	Reslit	Candidate
R23H	-	-	Staphylococcus aureus	teicoplanin	Reslit	Candidate
P101H	-	-	Staphylococcus aureus	oxacillin	Reslit	Candidate
-	G2209T	-	Staphylococcus aureus	teicoplanin	Reslit	Candidate
-	G2210A	-	Staphylococcus aureus	teicoplanin	Reslit	Candidate

Papers2

1

Teicoplanin stress-selected mutations increasing sigma(B) activity in Staphylococcus aureus.

PMID 11353616 · 2001

mutations in rsbW release sigma B from sequestration by RsbW

Mutation Information

rsbW: p.K44M rsbW: p.T52R rsbW: p.M1I rsbW: p.R23H rsbW: c.G2209T rsbW: c.G2210A

Protein Change: K44M, T52R, M1I, R23H
Nucleotide Change: G2209T, G2210A
Organisms: Staphylococcus aureus
Confers Resistance To: teicoplanin
Validation Method: sequencing and luciferase assay
Source Database: Reslit

2

Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics.

PMID 36507833 · 2023

Mutation Information

Protein Change: P101H
Organisms: Staphylococcus aureus
Confers Resistance To: oxacillin
Validation Method: mutant analysis
Source Database: Reslit