Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
anti-sigma factor
Overview
Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of Mycobacterium abscessus.
Loss-of-function mutations in the anti-sigma factor RshA confer low-level resistance to multiple antibiotic classes in Mycobacterium abscessus, including beta-lactams, DNA gyrase inhibitors, aminoglycosides, and tigecycline.
Durlobactam to boost the clinical utility of standard of care β-lactams against Mycobacterium abscessus lung disease.
The study identifies mutations in rhsA, mspA, and mmpL11 as mechanisms of resistance to IPM and FOX in Mycobacterium abscessus, and demonstrates that DUR-SUL can suppress the emergence of resistance.
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