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rstA

responsive regulator

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to rstA

Browse AMR rules for rstA

Overview

Mechanism: increased susceptibility to multiple antibiotics
Drug Classes: ampicillin|phenicols|gentamicin|kanamycin|lomefloxacin|tetracycline
Organisms: Pseudomonas fluorescens
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
D52A	-	increased susceptibility to multiple antibiotics	Pseudomonas fluorescens	ampicillin\|phenicols\|gentamicin\|kanamycin\|lomefloxacin\|tetracycline	Reslit	Candidate
D52E	-	increased susceptibility to multiple antibiotics	Pseudomonas fluorescens	ampicillin\|phenicols\|gentamicin\|kanamycin\|lomefloxacin\|tetracycline	Reslit	Candidate

Papers1

1

The Two-Component System RstA/RstB Regulates Expression of Multiple Efflux Pumps and Influences Anaerobic Nitrate Respiration in Pseudomonas fluorescens.

PMID 34726491 · 2021

Phosphorylation of Asp52 is crucial for RstA function.

Mutation Information

rstA: p.D52A rstA: p.D52E

Protein Change: D52A, D52E
Organisms: Pseudomonas fluorescens
Confers Resistance To: ampicillin|phenicols|gentamicin|kanamycin|lomefloxacin|tetracycline
Effect on Function: increased susceptibility to multiple antibiotics
Validation Method: mutant MIC testing
Source Database: Reslit