rv0678c

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putative membrane protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

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UniProt

Protein entries specific to rv0678c

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Validation StatusCandidate

Overview

Mechanism: confers resistance to bedaquiline and clofazimine
Validation Method: whole genome sequencing
Drug Classes: bedaquiline, clofazimine
Organisms: Mycobacterium bovis BCG, Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Challenging the gold standard: the limitations of molecular assays for detection of Mycobacterium tuberculosis heteroresistance.

PMID 38286614 · 2024

The study highlights the limitations of molecular assays in detecting Mycobacterium tuberculosis heteroresistance, showing that phenotypic testing (agar proportion method) can detect resistant populations at 1%, while molecular tests like GeneXpert and WGS have a higher limit of detection (around 10%).

Gene Information

Gene Name: rv0678c
Allele: Rv0678c
Encodes: putative membrane protein
Source Database: Reslit
Mechanism: confers resistance to bedaquiline and clofazimine
Confers Resistance To: bedaquilineclofazimine
Organisms Tested In: • Mycobacterium bovis BCG
• Mycobacterium tuberculosis
Validation Method: whole genome sequencing
Sequence Accession: SAMN38121993|SAMN38121994

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rv0678c

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rv0678c

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