sbmA

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inner-membrane peptide transporter

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to sbmA

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: loss of function increases resistance to aminoglycosides
Validation Method: whole-population genome sequencing
Drug Classes: amikacin
Organisms: Escherichia coli, E. coli
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A169E	-	-	E. coli	amikacin	Reslit	Candidate
L102P	CTG->CCC	-	Escherichia coli	amikacin	Reslit	Candidate

Papers3

Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance.

PMID 36928386 · 2023

The study identifies mutations in sbmA, fusA, and fimH genes that contribute to amikacin resistance in biofilm-forming E. coli. These mutations were selected during intermittent amikacin treatment, highlighting the role of biofilm environments in accelerating resistance evolution.

Gene Information

Gene Name: sbmA
Allele: sbmA
Encodes: inner-membrane peptide transporter
Source Database: Reslit
Mechanism: loss of function increases resistance to aminoglycosides
Confers Resistance To: amikacin
Organisms Tested In: • Escherichia coli
Validation Method: whole-population genome sequencing

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sbmA

Mutations

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sbmA

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