sco4121

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Major Facilitator Superfamily (MFS) efflux pump

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Validation StatusCandidate

Overview

Mechanism: efflux pump
Validation Method: Agar dilution and disc diffusion assays
Drug Classes: ciprofloxacin, phenicols, streptomycin, ethidium bromide
Organisms: Streptomyces coelicolor, Escherichia coli
Papers: 1
Databases: Reslit

Papers1

A Major Facilitator Superfamily (MFS) Efflux Pump, SCO4121, from Streptomyces coelicolor with Roles in Multidrug Resistance and Oxidative Stress Tolerance and Its Regulation by a MarR Regulator.

PMID 33483304 · 2021

The study identifies SCO4121, an MFS efflux pump in Streptomyces coelicolor, which confers resistance to multiple antibiotics including ciprofloxacin, chloramphenicol, streptomycin, and ethidium bromide. The pump is regulated by the MarR regulator SCO4122 and also contributes to oxidative stress tolerance.

Gene Information

Gene Name: sco4121
Allele: SCO4121
Encodes: Major Facilitator Superfamily (MFS) efflux pump
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: ciprofloxacinphenicolsstreptomycinethidium bromide
Organisms Tested In: • Streptomyces coelicolor
• Escherichia coli
Validation Method: Agar dilution and disc diffusion assays

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sco4121

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sco4121

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