sco4439

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D-alanyl-D-alanine carboxypeptidase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to sco4439

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: The spores of the SCO4439::Tn5062 mutant are affected in their resistance to heat and acid and showed a dramatic increase in swelling during germination. The mycelium of the SCO4439::Tn5062 mutant is more sensitive to glycopeptide antibiotics (vancomycin and teicoplanin).
Validation Method: mutant analysis and complementation
Drug Classes: glycopeptides
Organisms: Streptomyces coelicolor
Papers: 1
Databases: Reslit

Papers1

Characterization of SCO4439, a D-alanyl-D-alanine carboxypeptidase involved in spore cell wall maturation, resistance, and germination in Streptomyces coelicolor.

PMID 26867711 · 2016

The study characterizes SCO4439, a D-alanyl-D-alanine carboxypeptidase involved in spore cell wall maturation, resistance, and germination in Streptomyces coelicolor. Mutation of SCO4439 leads to increased resistance to acid and heat and decreased resistance to glycopeptides. The gene was experimentally validated through mutant analysis and complementation.

Gene Information

Gene Name: sco4439
Allele: SCO4439
Encodes: D-alanyl-D-alanine carboxypeptidase
Source Database: Reslit
Mechanism: The spores of the SCO4439::Tn5062 mutant are affected in their resistance to heat and acid and showed a dramatic increase in swelling during germination. The mycelium of the SCO4439::Tn5062 mutant is more sensitive to glycopeptide antibiotics (vancomycin and teicoplanin).
Confers Resistance To: glycopeptides
Organisms Tested In: • Streptomyces coelicolor
Validation Method: mutant analysis and complementation
Sequence Accession: WP_016326920|NP_824958|YP_006878621|WP_013002845|YP_001825771|WP_003961441

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sco4439

View on PubMed

D-alanyl-D-alanine carboxypeptidase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to sco4439

AMR Rules

Browse AMR rules for sco4439

Validation StatusCandidate

Overview

Mechanism: The spores of the SCO4439::Tn5062 mutant are affected in their resistance to heat and acid and showed a dramatic increase in swelling during germination. The mycelium of the SCO4439::Tn5062 mutant is more sensitive to glycopeptide antibiotics (vancomycin and teicoplanin).
Validation Method: mutant analysis and complementation
Drug Classes: glycopeptides
Organisms: Streptomyces coelicolor
Papers: 1
Databases: Reslit

Papers1

Characterization of SCO4439, a D-alanyl-D-alanine carboxypeptidase involved in spore cell wall maturation, resistance, and germination in Streptomyces coelicolor.

PMID 26867711 · 2016

Gene Information

Gene Name: sco4439
Allele: SCO4439
Encodes: D-alanyl-D-alanine carboxypeptidase
Source Database: Reslit
Mechanism: The spores of the SCO4439::Tn5062 mutant are affected in their resistance to heat and acid and showed a dramatic increase in swelling during germination. The mycelium of the SCO4439::Tn5062 mutant is more sensitive to glycopeptide antibiotics (vancomycin and teicoplanin).
Confers Resistance To: glycopeptides
Organisms Tested In: • Streptomyces coelicolor
Validation Method: mutant analysis and complementation
Sequence Accession: WP_016326920|NP_824958|YP_006878621|WP_013002845|YP_001825771|WP_003961441

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sco4439

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sco4439

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