sdexy

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RND efflux pump

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to sdexy

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: expression in E. coli and measurement of MICs
Drug Classes: norfloxacin, erythromycin, phenicols, tetracycline, benzalkonium chloride, triclosan, novobiocin, ethidium bromide
Organisms: Escherichia coli, Serratia marcescens
Papers: 1
Databases: Reslit

Papers1

Comprehensive analysis of resistance-nodulation-cell division superfamily (RND) efflux pumps from Serratia marcescens, Db10.

PMID 30890721 · 2019

The study identified and characterized multiple RND efflux systems in Serratia marcescens, including sdeXY, sdePQ, sdeAB, sdeGH, and sdeCDE, which confer resistance to various antimicrobial agents. The sdeXY deletion mutant showed increased susceptibility to multiple antimicrobial agents, highlighting the importance of these efflux systems in intrinsic multidrug resistance.

Gene Information

Gene Name: sdexy
Allele: sdeXY
Encodes: RND efflux pump
Source Database: Reslit
Confers Resistance To: norfloxacinerythromycinphenicolstetracyclinebenzalkonium chloridetriclosannovobiocinethidium bromide
Organisms Tested In: • Escherichia coli
• Serratia marcescens
Validation Method: expression in E. coli and measurement of MICs

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sdexy

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sdexy

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