Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
primary sigma factor
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G336C | - | reduces susceptibility to vancomycin and fosfomycin by altering promoter recognition. | Bacillus subtilis | vancomycin|fosfomycin | Reslit | Candidate |
| R515H | - | disrupting, knocking out, or mutating the gene causes SUSCEPTIBILITY | Mycobacterium smegmatis | spectinomycin|tetracycline|clarithromycin | Reslit | Candidate |
Mutations in the Primary Sigma Factor σA and Termination Factor Rho That Reduce Susceptibility to Cell Wall Antibiotics.
The sigA G336C mutation reduces susceptibility to vancomycin and fosfomycin by altering promoter recognition.
The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV).