sigB

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sigma factor

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to sigB

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: disruptive mutation
Validation Method: sequencing and phenotyping
Drug Classes: vancomycin
Organisms: Staphylococcus aureus
Papers: 1
Databases: Reslit

Papers1

Experimental evolution of Staphylococcus aureus in macrophages: dissection of a conditional adaptive trait promoting intracellular survival.

PMID 38682911 · 2024

The study identifies a novel S. aureus small colony variant (SCV) with a hyper-pigmented unstable phenotype and enhanced resistance to vancomycin, associated with mutations in rsbW and sigB.

Gene Information

Gene Name: sigB
Allele: sigB
Encodes: sigma factor
Source Database: Reslit
Mechanism: disruptive mutation
Confers Resistance To: vancomycin
Organisms Tested In: • Staphylococcus aureus
Validation Method: sequencing and phenotyping

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sigB

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sigB

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