sigR

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sigma factor

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UniProt

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Validation StatusCandidate

Overview

Mechanism: induction by translation-inhibiting antibiotics leads to increased stability and prolonged target gene expression
Validation Method: mutant analysis showing increased susceptibility to translation-inhibiting antibiotics
Drug Classes: phenicols, erythromycin, lincomycin, tetracycline
Organisms: Streptomyces coelicolor, Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Induction of a stable sigma factor SigR by translation-inhibiting antibiotics confers resistance to antibiotics.

PMID 27346454 · 2016

The study identifies sigR as a gene that, when induced by translation-inhibiting antibiotics, confers resistance to these antibiotics through the stabilization of the sigma factor SigR, which in turn enhances the expression of target genes.

Gene Information

Gene Name: sigR
Allele: sigR
Encodes: sigma factor
Source Database: Reslit
Mechanism: induction by translation-inhibiting antibiotics leads to increased stability and prolonged target gene expression
Confers Resistance To: phenicolserythromycinlincomycintetracycline
Organisms Tested In: • Streptomyces coelicolor
• Mycobacterium tuberculosis
Validation Method: mutant analysis showing increased susceptibility to translation-inhibiting antibiotics

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sigR

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sigR

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