Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
lytic transglycosylase
Overview
Loss of membrane-bound lytic transglycosylases increases outer membrane permeability and β-lactam sensitivity in Pseudomonas aeruginosa.
The study identifies that loss of specific lytic transglycosylases (slt, mltB, and sltB1) in Pseudomonas aeruginosa increases β-lactam sensitivity, indicating their role in maintaining outer membrane integrity and reducing antibiotic resistance.
Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria.
The study identified several genes and mutations associated with imipenem resistance in Gram-negative bacteria, including rpoD, amiC, nlpD, wecA, slt, and oprD, through mutagenesis and functional validation experiments.
Identification of Drug Resistance Determinants in a Clinical Isolate of Pseudomonas aeruginosa by High-Density Transposon Mutagenesis.
The study identifies several nonessential genes involved in β-lactam resistance in Pseudomonas aeruginosa, including ampC, mltG, mepM1, amgK, and ygfB, which contribute to the induction of ampC expression and resistance against meropenem and cefepime.
Lytic Transglycosylase Deficiency Increases Susceptibility to β-lactam Antibiotics But Reduces Susceptibility to Vancomycin in Escherichia coli.
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