Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
lytic transglycosylase
Overview
Changes to its peptidoglycan-remodeling enzyme repertoire modulate β-lactam resistance in Pseudomonas aeruginosa.
The study identifies dacB, sltB1, and mltB as genes whose loss increases β-lactam resistance in Pseudomonas aeruginosa through increased AmpC expression. Conversely, loss of slt and mltF decreases β-lactam resistance.
Loss of membrane-bound lytic transglycosylases increases outer membrane permeability and β-lactam sensitivity in Pseudomonas aeruginosa.
The study identifies that loss of specific lytic transglycosylases (slt, mltB, and sltB1) in Pseudomonas aeruginosa increases β-lactam sensitivity, indicating their role in maintaining outer membrane integrity and reducing antibiotic resistance.
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