Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
resistance-nodulation-cell division (RND) antibiotic efflux pump
Overview
Frequency and Genetic Determinants of Tigecycline Resistance in Clinically Isolated Stenotrophomonas maltophilia in Beijing, China.
The study identifies smeD overexpression as the primary genetic determinant of tigecycline, doxycycline, and levofloxacin resistance in clinical isolates of Stenotrophomonas maltophilia in Beijing, China.
Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens.
The study highlights the critical role of RND efflux pumps in mediating multidrug resistance in cystic fibrosis pathogens, particularly in Pseudomonas aeruginosa and Burkholderia cenocepacia. Several RND efflux systems were identified and characterized for their contributions to resistance against various antibiotics.
Soil Bacteria in Urban Community Gardens Have the Potential to Disseminate Antimicrobial Resistance Through Horizontal Gene Transfer.
The study identified various antimicrobial resistance genes (ARGs) in soil and vegetable bacteria from urban community gardens, highlighting the potential for horizontal gene transfer of resistance traits to clinically relevant pathogens.
The Contribution of Efflux Systems to Levofloxacin Resistance in Stenotrophomonas maltophilia Clinical Strains Isolated in Warsaw, Poland.
The study identifies that the overproduction of the SmeVWX efflux system plays a significant role in levofloxacin resistance in Stenotrophomonas maltophilia clinical isolates, while the SmeDEF system does not significantly contribute to levofloxacin resistance. Mutations in the regulatory genes smeT and smeRv were linked to the overexpression of these efflux systems.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
Screening and comparison of in vitro-induced resistant and clinically resistant Stenotrophomonas maltophilia strains for eravacycline resistance-related genes.
The study identified the upregulation of efflux pump genes (smrA, smeD, smeE, smeF) in eravacycline-resistant Stenotrophomonas maltophilia strains, along with copy number variations and nonsynonymous mutations in smeD, smeE, and smeF contributing to resistance.
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