Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
RND-type efflux transporter
Overview
The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants.
The study identifies multiple RND-type efflux pumps and beta-lactamases contributing to multidrug resistance in Stenotrophomonas maltophilia K279a, highlighting its extensive resistance mechanisms.
Comparative genomics of non-pseudomonal bacterial species colonising paediatric cystic fibrosis patients.
The study analyzed non-pseudomonal bacterial species from pediatric cystic fibrosis patients, identifying several AMR genes and mutations. Key findings include the presence of beta-lactamase genes (blaZ, blaI, blaRI) in Staphylococcus aureus, fosfomycin resistance gene fosB, fusidic acid resistance gene fusC, and efflux pumps smeZ, smeJ, and smeK in Stenotrophomonas maltophilia. Additionally, Enterobacter cloacae isolates carried resistance genes qacE delta 1, sul1, and dfrA5.
Stenotrophomonas maltophilia PhoP, a Two-Component Response Regulator, Involved in Antimicrobial Susceptibilities.
The study identified that the two-component regulator PhoP in Stenotrophomonas maltophilia is involved in antimicrobial susceptibilities, particularly in resistance to polymyxin B and aminoglycosides. The PhoP mutant showed increased susceptibility to several antibiotics, and the expression of the efflux transporter gene smeZ was downregulated in the phoP mutant.
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